The "Network Service" account and the AppPool identities can act as the computer account in terms of Active Directory, they are only restrained locally. Therefore it is possible to invoke S4U2self if you run as one of these and request a service ticket for any user (e.g. someone with local admin rights, like DA) to yourself.
```ps1
# The Rubeus execution will fail when trying the S4UProxy step, but the ticket generated by S4USelf will be printed.
* [Abusing S4U2Self: Another Sneaky Active Directory Persistence - Alsid](https://alsid.com/company/news/abusing-s4u2self-another-sneaky-active-directory-persistence)
* [Abusing Kerberos S4U2self for local privilege escalation - cfalta](https://cyberstoph.org/posts/2021/06/abusing-kerberos-s4u2self-for-local-privilege-escalation/)