diff --git a/Formula/gtk-doc.rb b/Formula/gtk-doc.rb
index 78d911319c1..e9cc26afff7 100644
--- a/Formula/gtk-doc.rb
+++ b/Formula/gtk-doc.rb
@@ -1,12 +1,14 @@
 class GtkDoc < Formula
+  include Language::Python::Virtualenv
+
   desc "GTK+ documentation tool"
   homepage "https://gitlab.gnome.org/GNOME/gtk-doc"
-  url "https://download.gnome.org/sources/gtk-doc/1.32/gtk-doc-1.32.tar.xz"
-  sha256 "de0ef034fb17cb21ab0c635ec730d19746bce52984a6706e7bbec6fb5e0b907c"
-  revision 2
+  url "https://download.gnome.org/sources/gtk-doc/1.33/gtk-doc-1.33.2.tar.xz"
+  sha256 "cc1b709a20eb030a278a1f9842a362e00402b7f834ae1df4c1998a723152bf43"
+  license "GPL-2.0-or-later"
 
-  # We use a common regex because gtk-doc doesn't use GNOME's "even-numbered
-  # minor is stable" version scheme.
+  # We use a common regex because gtk-doc doesn't use GNOME's
+  # "even-numbered minor is stable" version scheme.
   livecheck do
     url :stable
     regex(/gtk-doc[._-]v?(\d+(?:\.\d+)+)\.t/i)
@@ -21,41 +23,49 @@ class GtkDoc < Formula
     sha256 cellar: :any_skip_relocation, high_sierra:   "2e5f324a0c3e8aac532e8946fb00cc578d18184e8fb8d247329b7fbe252054b2"
   end
 
-  depends_on "itstool" => :build
+  depends_on "meson" => :build
+  depends_on "ninja" => :build
   depends_on "pkg-config" => :build
   depends_on "docbook"
   depends_on "docbook-xsl"
-  depends_on "gettext"
   depends_on "libxml2"
   depends_on "python@3.9"
-  depends_on "source-highlight"
 
   uses_from_macos "libxslt"
 
+  resource "anytree" do
+    url "https://files.pythonhosted.org/packages/d8/45/de59861abc8cb66e9e95c02b214be4d52900aa92ce34241a957dcf1d569d/anytree-2.8.0.tar.gz"
+    sha256 "3f0f93f355a91bc3e6245319bf4c1d50e3416cc7a35cc1133c1ff38306bbccab"
+  end
+
+  resource "lxml" do
+    url "https://files.pythonhosted.org/packages/e5/21/a2e4517e3d216f0051687eea3d3317557bde68736f038a3b105ac3809247/lxml-4.6.3.tar.gz"
+    sha256 "39b78571b3b30645ac77b95f7c69d1bffc4cf8c3b157c435a34da72e78c82468"
+  end
+
   resource "Pygments" do
-    url "https://files.pythonhosted.org/packages/7e/ae/26808275fc76bf2832deb10d3a3ed3107bc4de01b85dcccbe525f2cd6d1e/Pygments-2.4.2.tar.gz"
-    sha256 "881c4c157e45f30af185c1ffe8d549d48ac9127433f2c380c24b84572ad66297"
+    url "https://files.pythonhosted.org/packages/ba/6e/7a7c13c21d8a4a7f82ccbfe257a045890d4dbf18c023f985f565f97393e3/Pygments-2.9.0.tar.gz"
+    sha256 "a18f47b506a429f6f4b9df81bb02beab9ca21d0a5fee38ed15aef65f0545519f"
   end
 
   def install
-    # To avoid recording the shims path
-    ENV["PKG_CONFIG"] = Formula["pkg-config"].bin/"pkg-config"
+    # To avoid recording pkg-config shims path
+    ENV.prepend_path "PATH", Formula["pkg-config"].bin
 
-    xy = Language::Python.major_minor_version Formula["python@3.9"].opt_bin/"python3"
-    ENV.prepend_create_path "PYTHONPATH", libexec/"vendor/lib/python#{xy}/site-packages"
-    resource("Pygments").stage do
-      system Formula["python@3.9"].opt_bin/"python3", *Language::Python.setup_install_args(libexec/"vendor")
+    venv = virtualenv_create(libexec, "python3")
+    venv.pip_install resources
+    ENV.prepend_path "PATH", libexec/"bin"
+
+    args = std_meson_args + %w[
+      -Dtests=false
+      -Dyelp_manual=false
+    ]
+
+    mkdir "build" do
+      system "meson", *args, ".."
+      system "ninja", "-v"
+      system "ninja", "install", "-v"
     end
-
-    system "./configure", "--disable-debug",
-                          "--disable-dependency-tracking",
-                          "--prefix=#{prefix}",
-                          "--with-highlight=source-highlight",
-                          "--with-xml-catalog=#{etc}/xml/catalog"
-    system "make"
-    system "make", "install"
-
-    bin.env_script_all_files(libexec/"bin", PYTHONPATH: ENV["PYTHONPATH"])
   end
 
   test do
diff --git a/audit_exceptions/gnome_devel_allowlist.json b/audit_exceptions/gnome_devel_allowlist.json
index 4ebd67f4af5..b1471fc8fdf 100644
--- a/audit_exceptions/gnome_devel_allowlist.json
+++ b/audit_exceptions/gnome_devel_allowlist.json
@@ -1,4 +1,5 @@
 {
+  "gtk-doc": "1.33",
   "gtk-mac-integration": "2.1",
   "libart": "2.3",
   "libepoxy": "1.5"