diff --git a/Formula/glib.rb b/Formula/glib.rb
index 409e961936c..66ef96d475f 100644
--- a/Formula/glib.rb
+++ b/Formula/glib.rb
@@ -46,6 +46,12 @@ class Glib < Formula
 
     args << "--disable-debug" unless build_tests?
 
+    # MacPorts puts "@@PREFIX@@" in patches and does inreplace on the files,
+    # so we must follow suit if we use their patches
+    inreplace ['gio/xdgmime/xdgmime.c', 'gio/gdbusprivate.c'] do |s|
+      s.gsub! '@@PREFIX@@', HOMEBREW_PREFIX
+    end
+
     if ARGV.build_universal?
       # autoconf 2.61 is fine don't worry about it
       inreplace ["aclocal.m4", "configure.ac"] do |s|