diff --git a/src/utils/JupyterConnection.cpp b/src/utils/JupyterConnection.cpp
index 1f7f1fcf..46ddcb4f 100644
--- a/src/utils/JupyterConnection.cpp
+++ b/src/utils/JupyterConnection.cpp
@@ -8,6 +8,8 @@
 #include <QDebug>
 #include <QThread>
 #include <QFile>
+#include <QCoreApplication>
+#include <QDir>
 
 #include "JupyterConnection.h"
 #include "NestedIPyKernel.h"
@@ -39,11 +41,26 @@ JupyterConnection::~JupyterConnection()
 
         Py_Finalize();
     }
+
+    if (pythonHome)
+    {
+        PyMem_RawFree(pythonHome);
+    }
 }
 
 
 void JupyterConnection::initPython()
 {
+#ifdef APPIMAGE
+    // Executable is in appdir/bin
+    auto pythonHomeDir = QDir(QCoreApplication::applicationDirPath());
+    pythonHomeDir.cdUp();
+    QString pythonHomeStr = pythonHomeDir.absolutePath();
+    qInfo() << "Setting PYTHONHOME =" << pythonHomeStr << " for AppImage.";
+    pythonHome = Py_DecodeLocale(pythonHomeStr.toLocal8Bit().constData(), nullptr);
+    Py_SetPythonHome(pythonHome);
+#endif
+
     PyImport_AppendInittab("cutter", &PyInit_api);
     PyImport_AppendInittab("cutter_internal", &PyInit_api_internal);
     Py_Initialize();
diff --git a/src/utils/JupyterConnection.h b/src/utils/JupyterConnection.h
index ad775acc..b24258d9 100644
--- a/src/utils/JupyterConnection.h
+++ b/src/utils/JupyterConnection.h
@@ -5,6 +5,7 @@
 
 #include <QProcess>
 #include <QMap>
+#include <cwchar>
 
 class NestedIPyKernel;
 
@@ -44,6 +45,8 @@ private:
     QMap<long, NestedIPyKernel *> kernels;
     long nextKernelId = 1;
 
+    wchar_t *pythonHome = nullptr;
+
     void initPython();
     void createCutterJupyterModule();
 };